Diabetes mellitus (DM) is a health problem affecting millions of individuals worldwide. Diabetic\nnephropathy (DN), as a significant complication of DM, has become the most common cause of endstage\nrenal failure. Oxidative stress constitutes the key and common events in the pathogenesis of\nDN and antioxidants may play a beneficial role in its prevention. This study was conducted to investigate\nthe effect of Zinc Chloride on streptozotocin-induced diabetic nephropathy in rats compared\nto Gliclazide, a reference antidiabetic agent. Results showed that Zinc Chloride was able to\ncontrol STZ-induced DN in rats as it normalized the elevated blood pressure, the increased insulin\nrelease, and the decreased blood glucose level. Zinc Chloride also improved kidney function as\ndetermined by the restoration of blood urea and creatinine level. Finally, Zinc Chloride was able to\nboost the antioxidant defenses of the kidney by increasing the reduced glutathione content and\ndecreasing lipid peroxides content in addition to significantly decreasing kidney nitric oxide content\ncompared to diabetic control rats. These results suggest that exposure to Zinc Chloride can\nprotect from diabetic nephropathy and can be used as an adjuvant approach to treatment and prevention\nof renal damage.
Loading....